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ACTIV-2 Clinical Research Study


Hannibal Clinic’s Research Center is currently enrolling patients in their COVID-19 outpatient treatment research trial. Hannibal Clinic is one of only two Missouri sites chosen by the National Institutes of Health (NIH) to participate in ACTIV-2. The ACTIV-2 study is part of Operation Warp Speed, a public-private partnership created to fight the COVID-19 virus and gauge the effectiveness of different drugs in treating COVID-19 in outpatients. Its goals are to accelerate the development, manufacturing, and distribution of COVID-19 vaccines, therapeutics, and diagnostics.

Primary Investigator Humam Farah, MD, Director, Hannibal Clinic Research Center, and his team continue to help our community in the fight against COVID-19. 

What is the ACTIV-2 Study?

The ACTIV-2 Study is testing different investigational medicines to see if they can help adults with COVID-19. Researchers want to see if the medicines:

  • Are safe
  • Can help people get better faster
  • Can get rid of the virus
  • Can keep people from getting sicker
  • Can prevent people from having to go to the hospital

Who can join the ACTIV-2 Study?

This study is for adults 18 years and older who:

  • Recently tested positive for COVID-19
  • Are at home (not in the hospital)
  • Have symptoms of COVID-19

What happens during the study?

Permission: If you agree to be in the study, you will first give your permission by signing an Informed Consent Form.

Screening: You will then answer some questions to make sure the study is right for you.

Study Treatment: Different medicines are being studied to see which ones may work best. You will be placed by chance in a treatment group to receive one of these medicines. You will not be able to choose which group you are in.

Health Checks: You will have visits with tests as well as phone calls or video chats with the study team to check on your health. Some of the tests you may have include:

  • Blood pressure
  • Blood test
  • Checkup
  • Deep nose swab
  • Heart rate
  • Oxygen levels
  • Temperature
  • Weight

How do I join the ACTIV-2 Study?

If you tested positive for COVID-19 and are interested in learning more, call us at 573-231-3261

Or visit

Being in the study is voluntary and if you change your mind, you can leave the study at any time.